Canonical and Non-Canonical Roles of PFKFB3 in Brain Tumors
PFKFB3 is a bifunctional enzyme that modulates and maintains the intracellular concentrations of fructose-2,6-bisphosphate (F2,6-P2), essentially controlling the Lens Case rate of glycolysis.PFKFB3 is a known activator of glycolytic rewiring in neoplastic cells, including central nervous system (CNS) neoplastic cells.The pathologic regulation of PF